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白细胞介素1(IL-1)是单核吞噬细胞受刺激后产生的一种蛋白,对淋巴细胞激活和淋巴因子生成有刺激作用;还有诱发肝合成急性相反应蛋白、升高体温等多种生物作用。最近,美国 Dinarello 研究组报告,将人白细胞与新城病毒温育的上清液注入大鼠可使血浆皮质酮含量增加,而 IL-1抗体完全消除上消液的这种效应。以高度纯化或重组的人 IL-1注入 C3H/HeJ 小鼠,血清 ACTH 和皮质酮含量在注后2h 前后达到
Interleukin-1 (IL-1) is a protein produced by stimulation of mononuclear phagocytes, which stimulates lymphocyte activation and lymphokine production. It also induces acute phase reaction proteins such as liver synthesis and increases body temperature Biological effects. Recently, the United States Dinarello team reported that injection of a supernatant of human leukocytes incubated with Newcastle virus into rats increased plasma corticosterone levels, whereas IL-1 antibody completely abolished this effect of the upper body fluid. C3H / HeJ mice were injected with highly purified or recombinant human IL-1, serum ACTH and corticosterone levels reached before and after 2 h