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目的 :探讨免疫遗传学因素在瘢痕疙瘩发病机制中的作用。方法 :用聚合酶链反应 序列特异性引物 (PCR SSP)技术对 5 0例瘢痕疙瘩患者进行HLA Ⅱ类基因分型 ,并以 1 0 0例正常人的HLA Ⅱ类基因为对照。结果 :瘢痕疙瘩组HLA DQ5抗原频率 ( 3 0 % )明显高于对照组 ( 1 4% ) ,相对危险率 (RR) =2 .63 ;HLA DR1 7和HLA DQ8抗原频率 ( 2 % )明显低于对照组 ( 1 4% ,1 5 % ) ,RR =0 .1 3 ,0 .1 2。结论 :瘢痕疙瘩与HLA DQ5基因呈正相关 ,与HLA DR1 7和HLA DQ8基因呈负相关。HLA DQ5、HLA DR1 7和HLA DQ8基因可能是瘢痕疙瘩患者易感的单倍型
Objective: To investigate the role of immune genetics in the pathogenesis of keloid. Methods: HLA Ⅱ genotyping was performed on 50 cases of keloid patients by polymerase chain reaction sequence specific primers (PCR SSP) technique. The HLA Ⅱ gene of 100 normal subjects was used as control. Results: The frequency of HLA DQ5 antigen (30%) in keloid group was significantly higher than that in control group (14%). The relative risk (RR) was 2.63. The frequencies of HLA DR1 7 and HLA DQ8 antigen (2%) were significantly lower In the control group (14%, 15%), RR = 0.13, 0.12. Conclusion: Keloids are positively correlated with HLA DQ5 gene and negatively correlated with HLA DR1 7 and HLA DQ8 genes. HLA DQ5, HLA DR1 7, and HLA DQ8 genes may be susceptible haplotypes in keloid patients