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目的：探讨卡铂对恶性腹水腹腔化疗的疗效。方法：恶性腹水患者１０例，采用高效液相色谱法测定。卡铂３００ｍｇ／ｍ２加生理盐水７５０ｍｌ行快速腹腔注射，１６０～１８０ｍｉｎ取腹腔液、门静脉及外周血，２４０～２７０ｍｉｎ取癌组织、癌旁正常组织、腹膜、大网膜、阴性淋巴结测定总铂浓度。结果：腹腔液浓度最高，平均４８．１４ｕｌ／ｍｌ，门静脉次之１０．１ｕｌ／ｍｌ，分别是外周血的８和１．６倍。被测组织中，腹膜浓度超出其它组织浓度（Ｐ＜０．０５），癌组织含量高于正常组织。结论：卡铂腹腔化疗不仅提高腹腔、门静脉药物浓度，而且在腹膜、癌组织内有一定聚积性，对于杀灭腹腔亚临床病灶，改善临床分期，控制医源性转移，提高治愈率发挥重要作用。
Objective: To investigate the effect of carboplatin on intraperitoneal chemotherapy for malignant ascites. Methods: Ten patients with malignant ascites were measured by high performance liquid chromatography. Carboplatin 300mg/m2 plus saline 750ml fast intraperitoneal injection, peritoneal fluid, portal vein and peripheral blood were taken from 160 to 180 minutes, and the total platinum concentration was measured at 240 to 270 minutes from the cancer tissue, adjacent normal tissue, peritoneum, omentum, and negative lymph nodes. . RESULTS: The highest concentration of peritoneal fluid was 48.14 ul/ml in the abdominal cavity and 10.1 ul/ml in the portal vein, which was 8 and 1.6 times that of the peripheral blood, respectively. In the tested tissues, the peritoneal concentration exceeded that of other tissues (P<0.05), and the cancerous tissue content was higher than that of normal tissues. Conclusion: Carboplatin intraperitoneal chemotherapy not only increases the concentration of intraperitoneal and portal vein drugs, but also accumulates in the peritoneum and cancer tissues. It plays an important role in the killing of subclinical sub-clinical lesions, improving clinical staging, controlling iatrogenic metastases, and improving the cure rate. .