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胎盘生长因子(PlGF)最先发现于胎盘,属于血管内皮生长因子(VEGF)家族成员。PlGF和VEGF有42%的氨基酸序列相同,但两者的生物学功能却有统计学差异。PlGF可造成病理状况下的血管生成增多,使肺泡上皮细胞凋亡,与炎症反应、肿瘤细胞的生长、凋亡以及生殖、心血管和呼吸系统疾病的发生发展具有密切的关系。本研究就其结构、功能及与疾病的关系简单综述如下。
Placenta growth factor (PlGF) was first found in the placenta and belongs to the vascular endothelial growth factor (VEGF) family members. 42% of PlGF and VEGF have the same amino acid sequence, but the biological functions of both are statistically different. PlGF can cause increased angiogenesis under pathological conditions and apoptosis of alveolar epithelial cells, which is closely related to the inflammatory reaction, tumor cell growth and apoptosis, and the occurrence and development of reproductive, cardiovascular and respiratory diseases. This study briefly summarizes the relationship between its structure, function and disease.