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目的:研究汉黄芩素对脂多糖(LPS)诱导小胶质细胞激活时所分泌的白细胞介素6(interleukin6,IL-6)和趋化因子调节激活正常T细胞表达和分泌因子(regulated upon activation,normal Tcell expressed and secreted,RANTES)的影响。方法:采用体外LPS诱导小胶质细胞活化模型,用ELISA测定细胞外液中IL-6和RANTES的含量。结果:LPS能激活小胶质细胞并且能使IL-6和RANTES分泌增加,汉黄芩素明显抑制IL-6和RANTES的含量。结论:汉黄芩素有抑制LPS所致小胶质细胞IL-6和RANTES分泌的作用。
OBJECTIVE: To investigate the effects of wogonin on the secretion of interleukin-6 (IL-6) and chemokines secreted by lipopolysaccharide (LPS)-induced microglial activation and activation of normal T cell expression and secretion factors (regulated upon activation). The effect of normal Tcell expressed and secreted (RANTES). Methods: In vitro LPS-induced microglial activation model was used to determine the content of IL-6 and RANTES in extracellular fluid by ELISA. RESULTS: LPS could activate microglia and increase the secretion of IL-6 and RANTES. Wogonin significantly inhibited the content of IL-6 and RANTES. Conclusion: Wogonin can inhibit the secretion of IL-6 and RANTES induced by LPS in microglia.