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目的:探讨以全血细胞减少为首发表现的急性白血病的临床特点。方法:回顾性分析111例急性白血病的临床资料。结果:以全血细胞减少为首发表现的急性白血病28例(25.2%),多见于急性髓细胞白血病(75%),尤其急性早幼粒细胞白血病。并发感染及出血症状比例较高,但髓外器官浸润较轻。外周血可见白血病细胞,骨髓象多表现为增生活跃,早期死亡率无明显增加,近期和远期疗效无差异。结论:全血细胞减少是急性白血病中常见的血象表现,并非预后不良标志,经标准方案化疗及加强支持治疗后疗效满意。
Objective: To investigate the clinical features of acute leukemia with pancytopenia as the first manifestation. Methods: A retrospective analysis of 111 cases of acute leukemia clinical data. Results: Thirty-eight cases (25.2%) of acute leukemia, with pancytopenia as the first manifestation, were more common in acute myeloid leukemia (75%), especially acute promyelocytic leukemia. Complications of infection and bleeding a higher proportion, but extramedullary organ infiltration lighter. Leukemic cells can be seen in peripheral blood, bone marrow as more active hyperplasia, no significant increase in early mortality, no difference in short-term and long-term efficacy. CONCLUSION: Pancytopenia is a common manifestation of blood in acute leukemia and is not a sign of poor prognosis. The curative effect is satisfactory after standard chemotherapy and intensive supportive care.