胆固醇仍被认为是动脉粥样硬化的主要致病因子之一,但当前用于治疗粥样硬化的多数药物仅着眼于抑制疾病的发展,而不影响胆固醇水平。本文通过对血液生化和主动脉形态学变化的观察以研究秋水仙碱对兔实验性动脉粥样硬化进程的影响。雌兔18只分为三组,体重2.3～3.8kg。组1为对照组,单给基础饲料;组2为高脂组,每天给椰子油1g/kg,胆固醇0.5g/kg,胆酸100mg/kg;组3为秋水仙 Cholesterol is still considered to be one of the major causative agents of atherosclerosis, but most drugs currently used to treat atherosclerosis focus only on inhibiting disease progression without affecting cholesterol levels. In this paper, the changes of blood biochemistry and aortic morphology were observed in order to study the influence of colchicine on experimental atherosclerosis in rabbits. 18 female rabbits are divided into three groups, weighing 2.3 ~ 3.8kg. Group 1 is the control group, single basal diet; Group 2 is high fat group, giving coconut oil 1g / kg, cholesterol 0.5g / kg, cholic acid 100mg / kg daily;