乳腺癌是严重威胁女性健康的恶性肿瘤之一,其特异性靶向治疗近年来已成为研究的热点。大量研究[1-2]结果表明,肿瘤细胞中的缝隙连接(gap junction,GJ)功能降低,而恢复或增强由连接蛋白(connexin,Cx)所形成的细胞间GJ功能可增强抗肿瘤药物的治疗作用。因此,采用包括GJ工具药、基因治疗等多种方式在内的治疗策略,通过改变乳腺癌细胞 Breast cancer is one of the most serious malignant tumors which threaten women’s health. The specific targeted therapy has become a hot spot in recent years. Numerous studies have shown that the function of gap junctions (GJs) in tumor cells is reduced, whereas the intercellular GJ function restored or enhanced by connexin (Cx) can enhance the anti-tumor drug Therapeutic effect. Therefore, the use of GJ tools, including gene therapy and other means, including treatment strategies, by changing the breast cancer cells