论文部分内容阅读
目的:了解婴儿感染B族链球菌(GBS)的红霉素、克林霉素耐药率及大环内酯-林可酰胺-链阳菌素B(MLSB)类抗菌药物耐药表型。方法:采用纸片扩散法检测婴儿感染GBS菌株对红霉素、克林霉素的敏感性,D试验检测红霉素对克林霉素的诱导耐药性。结果:本研究纳入的患儿中男16例,女15例,年龄3 h~5个月。GBS对红霉素、克林霉素的耐药率分别为80.6%、77.4%;对红霉素、克林霉素同时敏感的GBS 3株,占9.7%;对红霉素耐药、对克林霉素敏感的2株,占6.5%。23例(92.0%)内在型耐药(cMLSB),2例(8.0%)M型耐药,未发现诱导型耐药。结论:婴儿感染的B族链球菌对红霉素、克林霉素耐药率高,MLSB耐药表型以cMLSB为主,未发现诱导型耐药。
Objective: To understand the erythromycin, clindamycin resistance rates and antibacterial phenotypes of macrolide - lincosamide - streptogramin B (MLSB) in infants infected with Group B Streptococcus. Methods: The sensitivity of GBS strain to erythromycin and clindamycin was tested by disk diffusion method. D test was used to detect the resistance of erythromycin to clindamycin. Results: There were 16 males and 15 females in this study, ranging in age from 3 h to 5 months. The resistance rates of GBS to erythromycin and clindamycin were 80.6% and 77.4%, respectively. GBS strains sensitive to erythromycin and clindamycin were 9.7%, resistant to erythromycin, Clindamycin sensitive 2, accounting for 6.5%. 23 cases (92.0%) were resistant to cMLSB and 2 cases (8.0%) were resistant to M type, and no induction of drug resistance was found. Conclusion: The infants infected with Streptococcus group B have high resistance rates to erythromycin and clindamycin, while the MLSB resistant phenotype is mainly cMLSB, and no inducible resistance is found.