论文部分内容阅读
目的从流行病学和病原学两方面对2011年-2015年锦州市流感的流行特征进行分析。方法从中国流感监测信息系统中收集锦州市2011年-2015年流行病学和病原学监测资料。采用Excel 2003进行数据统计描述,SPSS17.0软件进行数据分析。随机选取锦州市H3N2病毒进行病毒RNA提取,扩增目的基因片段,构建分子进化树,进行进化分析。结果 2011年-2015年医院共上送ILI标本6 031份,培养流感病毒211株,阳性率为3.50%。流感病毒未发生明显变异,毒株变异幅度不大,未发现有意义的耐药位点的出现和改变。结论锦州流感病毒活动比较平稳,各亚型交替成为流行的优势株。锦州市流感流行株与疫苗株有较好的一致性,大多数流感流行株对现有临床上应用的抗流感病毒的神经氨酸酶抑制剂仍然敏感。
Objective To analyze the epidemiological characteristics of influenza in Jinzhou city from 2011 to 2015 from epidemiology and etiology. Methods The epidemiological and etiological surveillance data of Jinzhou from 2011 to 2015 were collected from China Influenza Surveillance Information System. Using Excel 2003 for statistical data description, SPSS17.0 software for data analysis. Randomly selected virus H3NA2 Jinzhou virus RNA extraction, amplification of the target gene fragment, the construction of molecular phylogenetic tree, evolutionary analysis. Results From 2011 to 2015, a total of 6 031 ILI specimens were sent to the hospital for cultivation of 211 influenza viruses with a positive rate of 3.50%. Influenza virus did not change significantly, the extent of strain variation was not found significant changes in the emergence of drug-resistant sites. Conclusion The activity of influenza virus in Jinzhou was relatively stable, and all the subtypes became the predominant strains of epidemic. Most of the pandemic flu strains are still sensitive to the currently available anti-influenza virus neuraminidase inhibitors.