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本实验通过测定60Co辐射灭菌前后的三种促黄体生成素释放激素（LHRH）类似物（TX55、TX44、TX1）水溶液的含量变化及缓释微孔胶囊载体聚己内酯（PCL）的特性粘数[η]的变化说明：①辐射引起LHRH类似物的分解，TX55、TX44，TX1三种水溶液经不同剂量60Co辐射后含量均严重下降。②辐射引起PCL的特征粘数[η]下降．随着辐射剂量的增大，[η]值减小，缓释材料对辐射非常敏感，易引起降解、缓释材料分子量的降低必然影响其缓释药量的速度与时间。因此，当PCL作LHRH类似物载体时．不宜选用辐射作为其灭菌方法。
In this experiment, the content of three kinds of LHRH analogs (TX55, TX44, TX1) aqueous solution before and after 60Co radiation sterilization and the characteristics of sustained-release microcapsule carrier polycaprolactone (PCL) Viscosity [η] changes: ① radiation caused by the decomposition of LHRH analogues, TX55, TX44, TX1 three aqueous solutions after different doses of 60Co radiation were significantly decreased. ② radiation caused by the characteristic viscosity of PCL [η] decreased. With the increase of radiation dose, the value of [η] decreases, and the sustained-release material is very sensitive to radiation and easily causes degradation. The decrease of the molecular weight of sustained-release material will inevitably affect the speed and time of sustained release dose. Therefore, when PCL is used as LHRH analogue carrier. Radiation should not be used as a sterilization method.