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DC 参与胸腺 T 细胞的阴性选择过程,也参与外周 T 细胞的致耐。DC 可能是唯一具有胸腺 T 细胞阴性选择功能的细胞;在外周,DC 通过“否决”效应、诱导 T 细胞失能及其他一些机制诱导耐受生成。本文就此方面研究予以综述。
DC participates in the negative selection process of thymus T cells and is also involved in the induction of peripheral T cells. DCs may be the only cells that have a negative selection function for thymic T cells; peripherally, DCs induce “T cell dysfunction” through induction of “rejection” effects and other mechanisms that induce tolerance formation. This article reviews the research in this area.