论文部分内容阅读
目的研究ＣＫ７单克隆抗体在鉴别卵巢原发性癌和来源于胃肠道的卵巢转移性癌中的意义。方法采用免疫组织化学ＡＢＣ方法对４６例卵巢原发性癌、３４例原发灶在胃的卵巢转移性癌和３０例原发灶在肠的卵巢转移性癌进行了ＣＫ７单克隆抗体表达的检测。结果４６例卵巢原发性癌ＣＫ７均呈阳性表达，而３０例来源于肠的卵巢转移性癌ＣＫ７均为阴性，３４例来源于胃的卵巢转移性癌５０％呈ＣＫ７阳性表达。两组卵巢转移性癌的ＣＫ７阳性率与原发癌相比均有显著性差异（Ｐ＜０００１）。结论ＣＫ７单克隆抗体作为一个原发性卵巢癌的特异性标记，对鉴别卵巢原发性癌和来源于胃肠道的卵巢转移癌有重要意义
Objective To investigate the significance of CK7 monoclonal antibody in the identification of primary ovarian cancer and metastatic ovarian cancer derived from the gastrointestinal tract. Methods Immunohistochemistry ABC method was used to detect the expression of CK7 monoclonal antibody in 46 cases of primary ovarian cancer, 34 cases of primary metastatic ovarian cancer and 30 cases of primary metastatic ovarian cancer. . Results The positive expression of CK7 was detected in 46 cases of primary ovarian cancer, while 30 cases of ovarian metastatic carcinoma from the intestine were all negative for CK7, and 34 cases of metastatic ovarian cancer derived from stomach had CK7 positive expression. The positive rate of CK7 in both groups of ovarian metastatic carcinoma was significantly different from that of primary carcinoma (P<0001). Conclusion CK7 monoclonal antibody as a specific marker for primary ovarian cancer is important for the identification of primary ovarian cancer and ovarian metastasis derived from the gastrointestinal tract.