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目的 :探讨局灶性脑缺血再灌注后脑组织c -jun蛋白表达及川芎嗪、黄芪和尼莫通对其表达的影响。方法 :采用免疫组化与医学图像分析相结合的方法检测模型组及川芎嗪、黄芪、尼莫通干预组大鼠大脑皮层c -jun蛋白阳性细胞的平均灰度。结果 :①各组大鼠脑组织缺血侧c -jun蛋白阳性细胞平均灰度均低于无缺血侧 (P <0 .0 1) ;②各药物干预组缺血侧脑组织c -jun蛋白阳性细胞平均灰度均升高 (P <0 .0 1) ,其中尼莫通组升高更为显著 (P <0 .0 1)。结论 :局灶性脑缺血再灌注后脑组织c-jun蛋白表达显著升高 ;川芎嗪、黄芪和尼莫通均可部分抑制c -jun蛋白表达 ;尼莫通比川芎嗪、黄芪降低c -jun蛋白表达更显著。
Objective: To investigate the effect of ligustrazine, astragalus membranaceus and nimotop on the expression of c-jun protein in brain tissue after focal cerebral ischemia / reperfusion. Methods: The average gray level of c-jun protein positive cells in model group and ligustrazine, astragalus and nimotong intervention groups were detected by immunohistochemistry and medical image analysis. Results: ① The average gray level of c-jun positive cells in the ischemic side of rats in each group was lower than that in the non-ischemic side (P <0.01); ② The c-jun The average gray level of protein positive cells increased (P <0.01), of which the nimotopan group increased more significantly (P <0.01). Conclusion: The expression of c-jun protein in brain tissue after focal cerebral ischemia-reperfusion was significantly increased. Ligustrazine, Astragalus membranaceus and nimotop can partially inhibit the expression of c-jun protein. Jun protein expression more significant.