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用灵敏的凝血酶原蛇毒测定法,观察二乙基亚硝胺诱发大鼠肝癌过程中,血浆异常凝血酶原的动态变化。在诱癌第4周,大鼠血浆出现高水平的异常凝血酶原,约为正常对照组的10倍。此后持续上升至第13周;第15周有所下降,第20周又开始回升,表现为两个峰。诱癌早期的大鼠血浆即出现了高水平异常凝血酶原,它可用于肝癌的早期诊断。同时,还研究了华法令处理的大鼠血浆和肝再生大鼠血浆异常凝血酶原的变化。前者显著升高,后者却无明显变化。
Sensitive prothrombin venom assay was used to observe the dynamic changes of abnormal plasma prothrombin during diethylnitrosamine-induced rat liver cancer. At the 4th week of cancer induction, high levels of abnormal prothrombin were found in rat plasma, about 10 times that of the normal control group. After that, it continued to rise to the 13th week; it fell in the 15th week and began to rise again in the 20th week, showing two peaks. In the early stage of induction of cancer, high levels of abnormal prothrombin appear in rat plasma, which can be used for the early diagnosis of liver cancer. At the same time, changes in abnormal plasma prothrombin levels in rats treated with warfarin plasma and liver regeneration were studied. The former significantly increased while the latter did not change significantly.