【摘 要】
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Dear Editor,Protein domain is usually defined as distinct, compact and stable protein structural unit that folds independently of other such units (Koonin et al
【机 构】
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Genome Institute of Singapore, A*STAR, Singapore 138672,Singapore“,”Tianjin International Joint Acad
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Dear Editor,Protein domain is usually defined as distinct, compact and stable protein structural unit that folds independently of other such units (Koonin et al., 2002).The majority of proteins,especially in higher organisms, contain multiple domains (Chothia, 1992).Domain view of protein evolution provides many insights into the evolution of pathways and networks,as well as into the general direction of evolution of higher organisms.Domain structure of proteins is also important in understanding protein-protein interactions, as proteins interact with each other not as complete units, but rather via their component domains.Therefore, a protein-protein interaction (PPI) network can be viewed, at higher resolution, as the domain-domain interaction (DDI) network.However the network study in the past decade was still limited to protein but barely zoomed into domain resolution.Although some DDI-based database has been established and analyzed (Stein et al., 2005;Yellaboina et al., 2011), it remains unclear that how different domains play distinct roles in the interaction network and how do they coordinate with each other functionally.
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