【摘 要】
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Dear Editor,For decades, the stem cell field has pursued the development of humanized mice to further enhance our understanding of human hematopoiesis, innate i
【机 构】
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Peking University Stem Cell Research Center, Department of Cell Biology, School of Basic Medical Sci
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Dear Editor,For decades, the stem cell field has pursued the development of humanized mice to further enhance our understanding of human hematopoiesis, innate immunity,infectious diseases, cancer biology and regenerative medicine.One significant breakthrough in generating humanized mice was the development of NOD-scid II2rg-/-mice, which are double homozygous for the severe combined immunodeficiency (SCID) mutation and interleukin-2Rg (ll-2Rg)allelic mutation (gamma c null) (Ito et al., 2002).
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