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BALB/C系小白鼠经5 atm高压氧暴露可引起高压氧惊厥发作。预先给动物腹腔内注射8 mmol/kg DABA,可减少动物高压氧惊厥发作及延长发作潜伏期,但有明显的毒性。本文结果显示高压氧惊厥发作和GABA代谢障碍有关。
Exposure of BALB/C mice to hyperbaric oxygen at 5 atm can cause hyperbaric episodes. Intraperitoneal injection of 8 mmol/kg DABA to animals can reduce the risk of hyperbaric oxygen convulsive seizures and prolonged attack latency, but it has obvious toxicity. The results of this study show that hyperbaric seizures are associated with GABA metabolic disorders.