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提供准备好的肿瘤组织和恰当地调节生长环境,是肿瘤研究的必需条件。其中以体内方法比较适宜,因为在形态学上类似于原来的组织、治疗时便于确定疗效与毒性作用的比例以及可以研究那些通过改变内在环境间接地影响肿瘤生长的各种物质。然而将肿瘤移植到特定的部位、未成熟的和常规免疫抑制的受体来观察肿瘤存活率是不可靠的。本文报导,人体肿瘤组织移植在细胞免疫缺损的小鼠体内的结果。将4周大小的雌性CBA小鼠作胸腺切除,2周后全身照射900拉德X-线,并在24小时内静脉注射5×10~6同种异体骨髓细胞,
Providing prepared tumor tissue and properly regulating the growth environment are necessary conditions for tumor research. Among them, in vivo methods are more appropriate because they are similar in morphology to the original tissue, the ratios that facilitate the determination of efficacy and toxicity during treatment, and the various substances that can indirectly influence the growth of tumors by changing the intrinsic environment. However, it is not reliable to monitor tumor survival by transplanting tumors to specific sites, immature and conventional immunosuppressive receptors. This article reports the results of human tumor tissue transplants in vivo in mice with immunodeficiency. Four-week-old female CBA mice were subjected to thymectomy. After 2 weeks, 900-radad X-rays were irradiated to the entire body, and 5×10-6 allogeneic bone marrow cells were intravenously injected within 24 hours.