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洋地黄自200年前 Withering 首次应用以来,目前仍是治疗心力衰竭(简称心衰)的主要药物。心衰时,洋地黄通过增强心肌收缩性,改善心脏机械性效率和增加心排血量,使心脏能以同等的氧耗量或小于用药前的氧耗量来完成较大的工作量。此外,洋地黄对某些室上性心律失常(快速房颤、室上性心动过速)的疗效也已肯定,该作用在房颤伴有充血性心衰的患者中特别显著,其作用途径主要是通过对传导组织(房室结)的直接影响,但部分
Digitalis has been the leading drug in the treatment of heart failure (HF) since Withering was first introduced 200 years ago. When heart failure, digitalis by increasing myocardial contractility, improve cardiac mechanical efficiency and increase cardiac output, the heart can be the same oxygen consumption or less than the amount of oxygen consumption before medication to complete a larger workload. In addition, the effect of digitalis on some supraventricular arrhythmias (rapid atrial fibrillation, supraventricular tachycardia) has also been affirmed, the role of atrial fibrillation in patients with congestive heart failure is particularly significant, its role in the pathway Mainly through direct effects on the conductive tissue (atrioventricular node), but in part