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DNA双链断裂(double strand breaks,DSBs)是细胞最严重的DNA损伤形式。细胞通过同源重组(homologous recombination,HR)和非同源末端连接(non-homologous end joining,NHEJ)途径修复DNA双链断裂损伤。聚腺苷二磷酸核糖基化(poly(ADP-ribosyl)ation,PARylation)是蛋白质翻译后修饰过程,这个过程由聚腺苷二磷酸-核糖聚合酶家族(poly(ADP-ribose)polymerases,PARPs)催化完成。PARP1作为PARPs家族最重要的成员,其在DNA损伤应答方面发挥重要作用。研究显示,PARP1在DSBs修复过程中发挥关键作用,参与DSBs的早期应答反应及其具体修复途径,可依据KU蛋白的存在与否发挥不同的特定作用。本文较全面地综述了PARP1在DNA双链断裂修复方面的潜在作用,将为临床疾病的诊治提供新的思路。
DNA double strand breaks (DSBs) are the most severe forms of DNA damage in cells. Cells repair DNA double-strand breaks through homologous recombination (HR) and non-homologous end joining (NHEJ) pathways. Poly (ADP-ribosyl) ation (PARylation) is a post-translational modification of protein. This process consists of poly ADP-ribose polymerases (PARPs) Catalytic completion. PARP1, the most important member of the PARPs family, plays an important role in DNA damage response. Studies have shown that PARP1 play a key role in the repair process of DSBs. It is involved in the early response of DSBs and its specific repair pathway, which may play different specific roles depending on the presence or absence of KU protein. This article provides a comprehensive review of the potential role of PARP1 in the repair of DNA double-strand breaks, which will provide new insights into the diagnosis and treatment of clinical diseases.