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心肌中存在一定数量的内源性啡肽类物质,通过降低心肌耗氧量来局部调节心脏功能。降钙素基因相关肽(CGRP)广泛存在于中枢神经系统和心血管系统中,在血管外膜的神经结构中存在大量有免疫活性的CGRP,它具有正性变力和变时的作用,并有强烈扩张外周血管的作用,心梗时其血浆浓度明显增高可能介导心肌疼痛。早期研究已表明在严重的冠脉疾病中脊髓电刺激(SCS)有抗心绞痛和抗心肌缺血的作
There are a number of endogenous propeptides in the myocardium that regulate local cardiac function by reducing myocardial oxygen consumption. CGRP is widespread in the central nervous system and cardiovascular system. There are a large number of immunocompetent CGRP in the neural structure of vascular adventitia, and it has positive variable and time-varying effects A strong expansion of the role of peripheral blood vessels, myocardial infarction significantly increased plasma concentrations may be mediated by myocardial pain. Earlier studies have shown that spinal cord electrical stimulation (SCS) has anti-anginal and anti-myocardial ischemia in severe coronary artery disease