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醋酸棉酚给药4周后,大鼠睾丸晚期精子细胞螺旋鞘线粒体肿胀、空泡化,轴丝体裸露。中、早期精子细胞和初级精母细胞线粒体肿胀、空泡化,数目减少,伴内质网扩张。另见中期头帽,顶体肿胀,或出现裂隙。早期高尔基体空泡化,顶体颗粒退化。支持细胞多形线粒体增多,脂滴、溶酶体增多,其后内质网明显扩张。给药8周后,部分精原细胞线粒体亦受损,核膜皱缩或破损。支持细胞间的紧密联接复合体结构大部分丧失。间质细胞的超微结构未见明显变化。
Four weeks after administration of gossypol acetate, the mitochondria of rat sperm cells in the late stage of testicular sperm were swollen, vacuolized and axonal bodies were exposed. In early sperm cells and primary spermatocytes, mitochondria were swollen, vacuolized and the number decreased with endoplasmic reticulum dilatation. See also mid-cap, acrosome swelling, or cracks. Early Golgi vacuole, acrosome degradation. Support cells increased polymorphonuclear mitochondria, lipid droplets, lysosomes increased, followed by significant expansion of the endoplasmic reticulum. After 8 weeks of administration, some spermatogonial mitochondria were also damaged, and the nuclear membrane was shrunk or damaged. Most of the structures that support tight junctions between the complexes are lost. The ultrastructure of stromal cells showed no significant changes.