Indoprofen (α[4-(2-异氮茚满基-1-酮基)-苯基]丙酸)是非甾体镇痛消炎药。分子中有一不对称碳原子,故有(S)-(+)、(R)-(-)二种光学异构体与外消旋化合物。本文研究光学对映体及其外消旋化合物的生物活性及毒性。动物试验表明:外消旋物、(S)-(+)、(R)-(-)异构体抗角叉菜胶引起大白鼠水肿的半数有效剂量(mg/ Indoprofen (α [4- (2-Isoindan-1-yl) -phenyl] propionic acid) is a non-steroidal analgesic anti-inflammatory drug. Molecular has an asymmetric carbon atoms, it is (S) - (+), (R) - (-) two optical isomers and racemic compounds. This article studies the optical activity and toxicity of optical enantiomers and their racemic compounds. Animal experiments show that: racemic, (S) - (+), (R) - (-) isomers of carrageenan induced edema in rats half the effective dose (mg /