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目的:探讨非洛地平联合辛伐他汀治疗高血压并颈动脉斑块是否具有协同作用。方法:选取我院2006年7月—2009年6月于我院治疗的高血压并颈动脉斑块患者共76人,将其随机分为非洛地平联合辛伐他汀组40例和其他非钙离子拮抗剂联合辛伐他汀组36例。两组均给予辛伐他汀20mg,1次/d;非洛地平+辛伐他汀组加用非洛地平(5~10mg,1次/d)。疗程24周。用彩色多普勒超声检测患者治疗前后颈动脉内膜-中膜厚度、颈动脉粥样硬化斑块面积以及血脂水平。结果:治疗后复查,两组患者颈动脉斑块均有改善,疗效确切,非洛地平联合辛伐他汀治疗组总有效率90.50%,辛伐他汀+其他非钙离子拮抗剂降压药组总有效率75.60%,非洛地平+辛伐他汀组疗效优于辛伐他汀+其他非钙离子拮抗剂降压药组(P<0.01)。结论:非洛地平联合辛伐他汀对治疗高血压颈动脉斑块有确切疗效。
Objective: To investigate whether felodipine and simvastatin have synergistic effect on hypertension and carotid plaque. Methods: A total of 76 hypertensive patients with carotid artery plaque in our hospital from July 2006 to June 2009 were selected and randomly divided into 40 cases of felodipine and simvastatin group and other non-calcium Ion antagonist combined simvastatin group of 36 cases. Both groups were given simvastatin 20mg, 1 / d; felodipine + simvastatin group with felodipine (5 ~ 10mg, 1 / d). Treatment for 24 weeks. Carotid intima - media thickness, carotid atherosclerotic plaque area and serum lipid levels before and after treatment were measured by color Doppler sonography. Results: After treatment, carotid plaques were improved in both groups, and the curative effect was definite. The total effective rate was 90.50% in the combination of felodipine and simvastatin, and the total effective rate of simvastatin plus other non-calcium antagonist antihypertensive drugs The effective rate was 75.60%. The felodipine + simvastatin group was superior to simvastatin + other non-calcium antagonist antihypertensive drugs (P <0.01). Conclusion: Felodipine combined with simvastatin has definite curative effect on hypertensive carotid artery plaque.