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目的探讨本地区老人幽门螺杆菌(Hp)cag A基因存在状况及其与老年胃十二指肠病的关系。方法收集89例老年和96例青壮年慢性胃炎、消化性溃疡患者及30例正常对照人群的血清标本及胃组织标本,应用血清学检验其Hp-cag A阳性菌株感染状况。结果89例老年患者中慢性胃炎、胃溃疡、十二指肠溃疡的Hp-cag A基因的阳性率分别为73.5%(38/52)、81.3%(13/16)及85.7%(18/21);96例青壮年患者中慢性胃炎、胃溃疡、十二指肠溃疡的Hp-cag A基因的阳性率分别为59.3%(32/54)、68.8%(11/16)及61.5%(16/26);对照组Hp-cag A阳性菌株感染率为33.3%。各疾病组间Hp-cag A阳性菌株感染率差异无显著性(P>0.05),但均高于对照组(P<0.05);cag A阳性Hp菌株感染率老年组高于青壮年组(P<0.05)。结论本地区老年患者cag A阳性Hp菌株感染与上述3种胃十二指肠疾病的发生均密切相关,老年患者感染的Hp绝大多数为cag A阳性菌株。
Objective To investigate the presence of cag A gene of Helicobacter pylori (H. pylori) in the elderly and its relationship with gastroduodenal disease in the elderly. Methods Serum samples and gastric tissue samples of 89 elderly and 96 young adults with chronic gastritis, peptic ulcer and 30 normal controls were collected and serologically tested for the infection status of Hp-cag A positive strains. Results The positive rates of Hp-cag A gene in chronic gastritis, gastric ulcer and duodenal ulcer in 89 elderly patients were 73.5% (38/52), 81.3% (13/16) and 85.7% (18/21) respectively ). The positive rates of Hp-cag A gene in chronic gastritis, gastric ulcer and duodenal ulcer in 96 young adults were 59.3% (32/54), 68.8% (11/16) and 61.5% (16.5%) respectively / 26). The infection rate of Hp-cag A positive strains in the control group was 33.3%. The infection rates of Hp-cag A positive strains in each disease group were not significantly different (P> 0.05), but were higher than those in control group (P <0.05). The infection rate of Hp-cag A positive strains was higher in aged group than in young group <0.05). Conclusion Infection of cag A positive Hp strains in elderly patients in the region is closely related to the occurrence of the above three kinds of gastroduodenal diseases. The majority of Hp infections in elderly patients are cag A positive strains.