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目的：观察ｎｍ２３基因在膀胱癌中的表达并探讨其临床意义。方法：对４７例膀胱癌标本进行Ｓ－Ｐ免疫组化染色，分析ｎｍ２３蛋白表达与膀胱癌多种指标和预后的关系。结果：ｎｍ２３蛋白在膀胱癌组织及非癌粘膜中均有表达，定位于细胞浆。７２．３４％的膀胱癌组织ｎｍ２３蛋白染色阳性，阳性率显著高于非癌粘膜（Ｐ＜０．０５）。ｎｍ２３蛋白高度表达与膀胱癌细胞的低度分化及局部浸润有关，与肿瘤复发及肿瘤大小无关。结论：在膀胱癌中ｎｍ２３基因可能不是转移抑制基因，相反却促进膀胱癌的发生和发展，ｎｍ２３蛋白对于判断膀胱癌细胞的恶性程度、肿瘤进展以及预后有价值。
Objective: To observe the expression of nm23 gene in bladder cancer and to explore its clinical significance. Methods: S-P immunohistochemical staining was performed in 47 cases of bladder cancer and the relationship between nm23 protein expression and various indexes and prognosis of bladder cancer was analyzed. Results: nm23 protein was expressed in bladder cancer tissues and non-cancerous mucosa, located in the cytoplasm. The positive rate of nm23 protein in 72.34% of bladder cancer tissues was significantly higher than that of non - cancerous mucosa (P <0.05). The high expression of nm23 protein is associated with the low differentiation and local infiltration of bladder cancer cells, which has nothing to do with tumor recurrence and tumor size. Conclusion: The nm23 gene may not be a metastasis suppressor gene in bladder cancer, on the contrary, it may promote the occurrence and development of bladder cancer. The nm23 protein is valuable in judging the malignant degree, tumor progression and prognosis of bladder cancer.