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目的:应用图像视觉诱发电位(PVEP)对不同眼病患者和正常眼进行检查,了解PVEP在对不同眼病的评估中的意义。方法:用PVEP检查67例不同眼病患者及48名正常视力志愿者。比较分析不同病变的PVEP波形变化特点。结果:同正常眼相比,急性期中心性浆液性视网膜脉络膜病变眼、视野显著缩小的视网膜色素变性眼、视野显著缺损的开角型青光眼、外伤性视神经损伤眼以及弱视眼较正常对照眼PVEP的振幅明显下降,N1及P1的峰时延迟;而视野无显著缩小到视网膜色素变性眼以及视野轻度缺损的开角型青光眼N1峰时、P1峰时及振幅与无显著统计学差异。结论:PVEP对黄斑部功能受损的疾病改变十分敏感,而对周边视野损害改变不甚敏感,在PVEP波形两种成分的改变中振幅的改变较峰时更为敏感。在眼外伤视神经损伤的病例中PVEP可用于判断患眼视力的预后,在弱视病例中也有助于发现病患和随访治疗效果。
Objective: To evaluate the significance of PVEP in the assessment of different eye diseases by using image visual evoked potentials (PVEP) in patients with different eye diseases and normal eyes. Methods: PVEP was used to examine 67 patients with different eye diseases and 48 normal vision volunteers. Comparative analysis of PVEP waveform changes in different lesions. Results: Compared with normal eyes, acute central serous chorioretinopathy eyes, significantly reduced visual field of retinitis pigmentosa, visual field defect, open angle glaucoma, traumatic optic nerve injury and amblyopia eyes than normal control eyes PVEP The peak amplitude of N1 and P1 was delayed; however, there was no significant difference between P1 peak amplitude and amplitude when there was no significant decrease in the visual field to N1 peak of open-angle glaucoma with retinitis pigmentosa and mild visual field defect. CONCLUSIONS: PVEP is very sensitive to disease with impaired macular function and less sensitive to changes in peripheral vision damage. Changes in amplitude of the two components of the PVEP waveform are more sensitive than those at peak. PVEP can be used to determine the prognosis of visual acuity in cases of ocular trauma and optic nerve injury, and in amblyopia cases can also help to identify patients and follow-up treatment.