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目的探讨O型孕妇检测ABO血型特殊抗体(IgG)效价滴度与其新生儿发生溶血反应机率预测价值。方法对我院2008年6月~2009年12月输血科检测的215例O型孕妇ABO血型特殊抗体结果及其新生儿发生溶血反应的实验室指标及临床资料进行回顾性调查研究。结果 215例O型孕妇检测ABO血型特殊抗体滴度结果Ⅰ组有87例,其新生儿溶血反应有1例,发生率为1.15%;Ⅱ组有46例,其新生儿发生溶血反应有3例,发生率为6.52%;Ⅲ组有54例,其新生儿发生溶血反应有8例,发生率为14.81%;Ⅳ组有17例,其新生儿溶血反应有6例发生率为35.29%;Ⅴ组有11例其新生儿溶血反应有9例,发生率为81.82%。结论 O型孕妇ABO血型特殊抗体检测抗体滴度越高,其发生新生儿溶血反应机率越大,且O型孕妇开展ABO血型特殊抗体检测对新生儿发生溶血反应有较高预测价值。
Objective To investigate the predictive value of detecting the titer of ABO blood group specific antibody (IgG) and the rate of hemolysis reaction in neonates with O-type pregnant women. Methods A retrospective investigation was conducted on the results of 215 cases of O-type pregnant women with ABO blood group antibodies detected in our hospital from June 2008 to December 2009 and the laboratory data and clinical data of hemolytic reaction in newborns. Results A total of 215 cases of O-type pregnant women with ABO blood group were detected for specific antibody titers. There were 87 cases in group Ⅰ and 1 case of hemolysis in neonates, the incidence was 1.15%. In group Ⅱ, 46 cases had hemolysis in 3 cases , The incidence was 6.52%; Ⅲ group of 54 cases, the newborn hemolytic reaction in 8 cases, the incidence was 14.81%; Ⅳ group of 17 cases, the rate of neonatal hemolytic reaction in 6 cases was 35.29%; Ⅴ Eleven patients had hemolytic reaction in 9 newborns, the incidence was 81.82%. Conclusion The higher the antibody titer of ABO blood type antibody in O pregnant women, the higher the chance of newborn hemolysis reaction is. The detection of ABO blood group special antibody in O pregnant women has a higher predictive value on hemolytic reaction in neonates.