为进一步比较抗生素８９－０７与庆大霉素（ＧＭ）、阿米卡星（ＡＭＫ）长期用药时对听力的影响，本研究用豚鼠２１４只，各注射不同药物与生理盐水，每种药物又分４～５个剂量组，每天肌注１次，共２８ｄ。给药期间，每周及完成给药计划后均检查听力与前庭功能。听力检查表明，抗生素８９－０７对听力的影响近于生理盐水水平，随时间延长及剂量积累也未见变化，即不具有明显的量效关系及时效关系。相反，ＧＭ与ＡＭＫ随给药时间延长，药物积累，与生理盐水的差异愈趋明显，量效关系高度显著。本实验的功能检查结果表明：氨基糖苷类新抗生素８９－０７对听力损伤极低，几乎没有耳蜗毒性，是值得推荐的一种新药 In order to further compare the effect of long-term administration of antibiotic 89-07 with gentamycin (GM) and amikacin (AMK) on hearing, 214 guinea pigs were injected with different drugs and saline, each of which Divided 4 ~ 5 dose group, intramuscular injection 1 times a day, a total of 28d. During the dosing period, hearing and vestibular function are examined weekly and after completion of the dosing schedule. Hearing tests showed that the effect of antibiotic 89-07 on hearing was close to that of saline, and no change was observed over time and dose accumulation, that is, there was no obvious dose-response and time-effect relationship. On the contrary, GM and AMK prolonged with drug delivery, drug accumulation, and the difference between saline and the more obvious, the dose-effect relationship was highly significant. The functional test results of this experiment show that the new aminoglycoside antibiotic 89-07 has very low hearing loss and little cochlear toxicity and is a new drug worth recommending