Neptunium is one of the primary focuses in the analysis of reprocessing process,which is strictly controlled in the uranium product.It remains to be difficult to achieve the real time determination of trace neptunium in the existence of a large quantity of uranium.In this work,TTA extraction and anion exchange separation were combined for effective rapid separation of trace Neptunium is one of the primary focuses in the analysis of reprocessing process, which is strictly controlled in the uranium product. It remains to be difficult to achieve the real time determination of trace neptunium in the existence of a large quantity of uranium. In this work TTA extraction and anion exchange separation were combined for effective rapid separation of trace