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异丙肾上腺素(ISP)是一种强有力的心脏毒性物质。给动物注射一定剂量可引起明显心肌坏死。糖尿病时可发生心肌病改变,为探讨糖尿病心肌对致损伤因素的反应特点,本实验研究了糖尿病状态对ISP所致心肌坏死的影响。由于甲状腺功能状态可影响儿茶酚胺的反应性,故同时也探讨了糖尿病大鼠血清甲状腺激素水平对这种心肌坏死的影响。
Isoproterenol (ISP) is a potent cardiotoxic substance. Injection of certain doses to animals can cause significant myocardial necrosis. Diabetes mellitus can occur during cardiomyopathy, in order to investigate the characteristics of diabetic myocardial response to injury, this study investigated the impact of diabetic status on ISP induced myocardial necrosis. As thyroid function can affect the reactivity of catecholamines, it also explores the diabetic rats serum thyroid hormone levels of this myocardial necrosis.