过去一向认为钙拮抗剂(ＣＣＢ)扩血管作用机制是血管平滑肌Ｌ型钙通道,减少细胞内钙,使平滑肌松弛。近年来,实验证明ＣＣＢ对血管内皮细胞的作用,也是其作用机制之一。其事实为:(1)冠脉预先用ＰＧＦ2α处理使冠脉收缩,这时尼群地平的扩冠脉作用,可被甲基兰阻断;因为已经证明甲 Traditionally, it has been suggested that the mechanism by which calcium antagonists (CCBs) vasodilators act is the L-type calcium channel of vascular smooth muscle, reducing intracellular calcium and relaxing smooth muscle. In recent years, experiments show that the role of CCB on vascular endothelial cells, but also one of the mechanisms of action. The fact is: (1) coronary artery pre-treatment with PGF2α contraction of the coronary artery, when the role of broad-spectrum coronary artery of nitrendipine can be blocked by methyl blue; because a