核苷类化疗药物是临床上常见的抗癌药,用于多种癌症的治疗。此类药物需要通过细胞膜上的核苷转运体进入细胞,为提高药物的抗癌效果及研究癌细胞的耐药性机制,开发新的抗肿瘤药物,就需对核苷转运体及其跨膜转运机制有充分的认识。核苷转运体有两类,即平衡型核苷转运体(ENT)和浓度型核苷转运体(CNT)。其中ENT是主要的转运蛋白,分布广,底物选择性低,起着十分重要的作用。本文对ENT在细胞水平的研究进展作一综述。 Nucleoside chemotherapy drugs are clinically common anti-cancer drugs, for a variety of cancer treatment. Such drugs need to enter the cells through nucleoside transporters on the cell membrane, in order to improve the anticancer effect of drugs and study the mechanism of cancer drug resistance, the development of new anti-tumor drugs, the need for nucleoside transporter and its transmembrane Transport mechanism has a full understanding. There are two types of nucleoside transporters: the balanced nucleoside transporter (ENT) and the concentrated nucleoside transporter (CNT). Which ENT is the main transporter, widely distributed, low substrate selectivity, plays a very important role. This article reviews the progress of ENT at the cellular level.