方法：采用流式细胞术和３Ｈ－ＴｄＲ渗入法。目的：分析肾综合征出血热病毒Ｒ２２株感染对人血管内皮细胞（ＨＥＣｓ）的细胞周期和细胞ＤＮＡ合成率的影响。结果：病毒感染可明显延缓ＨＥＣｓ细胞周期进程，降低细胞ＤＮＡ合成率，细胞增殖受到明显的抑制，结论：ＨＦＲＳ病毒对ＨＥＣｓ有直接致病作用 Methods: Flow cytometry and 3H-TdR infiltration method. Objective: To analyze the effect of R22 infection with hemorrhagic fever with renal syndrome virus on the cell cycle and DNA synthesis rate of human vascular endothelial cells (HECs). Results: The virus infection could delay the cell cycle progression of HECs, reduce the rate of cell DNA synthesis, and significantly inhibit cell proliferation. Conclusion: The HFRS virus has a direct pathogenic effect on HECs