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丙戊酸通过抑制组蛋白去乙酰化酶(HDAC)的活性,特异性降解HDAC2,以及caspase依赖及非依赖途径诱导凋亡,在恶性血液病中的治疗作用越来越受到重视。本文就丙戊酸治疗恶性血液病的机制及目前进行的临床研究作一综述。
Valproic acid is gaining more and more attention in the treatment of hematologic malignancies by inhibiting the activity of histone deacetylase (HDAC), specifically degrading HDAC2, and inducing apoptosis in a caspase-dependent and non-dependent manner. This article reviews the mechanism of valproic acid in the treatment of hematologic malignancies and the current clinical research.