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目的:为探讨疱疹止痛灵治疗带状疱疹后遗神经痛的效果和镇痛作用机理。方法:对疱疹止痛灵进行了系统的临床观察和动物实验研究。结果:临床应用疱疹止痛灵治疗带状疱疹后遗神经痛315 例,总有效率96.5% ,而对照组79 例,总有效率 44.3% ,结果显示治疗组优于对照组(P< 0.01)。结论:经临床及实验研究结果表明,疱疹止痛灵不仅能有效治疗带状疱疹后遗神经痛,而且实验证明,疱疹止痛灵镇痛作用对于外周交感神经末稍有阻断作用 止痛作用,而对侧脑室给予疱疹止痛灵无镇痛作用。从而证明该药止痛部位在外周交感神经末稍,而不是神经中枢
Objective: To investigate the effect and analgesic mechanism of Herpes Zhitongling in treating postherpetic neuralgia. Methods: Herpes and painkillers conducted a systematic clinical observation and animal experiments. Results: Herpes Zhitongling treatment 315 cases of postherpetic neuralgia, the total effective rate 96.5%, while the control group 79 cases, the total effective rate 44.3%, the results showed that the treatment group was better than the control group (P <0.01). Conclusion: The results of clinical and experimental studies show that Herpes Zhi Tong Ling can not only effectively treat postherpetic neuralgia, but also proved that herpes and analgesic analgesia can block the peripheral sympathetic nerve analgesia, and Intracerebroventricular injection herpes analgesic no analgesic effect. This proves that the drug analgesic site in peripheral sympathetic nerve endings, rather than the nerve center