糖尿病肾病是糖尿病的主要慢性并发症。糖代谢紊乱在其发病机制中起着重要的作用 ,葡萄糖转运蛋白是调节葡萄糖进入系膜细胞的主要载体 ,其可能通过糖代谢途径 ,蛋白激酶C(PKC)途径 ,转化生长因子 (TGF) β1等细胞因子及基因背景等多因素途径参与糖尿病肾病的发生发展。 Diabetic nephropathy is a major chronic complication of diabetes. The disorder of glucose metabolism plays an important role in its pathogenesis. Glucose transporter is the main carrier regulating glucose into mesangial cells, which may be through the pathway of glucose metabolism, protein kinase C (PKC), transforming growth factor (TGF) And other cytokines and genetic background and other multi-factor pathways involved in the occurrence and development of diabetic nephropathy.