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目的 了解原发性肝癌患者介入治疗前的生命质量和术后变化情况。资料与方法 采用万崇华等编制的肝癌特异性生命质量评定量表对广东省 3家医院 175例经介入治疗的原发性肝癌患者进行生命质量评定。调查时间为介入术前、术后 1个月及 3个月 ,对 3个时点的生命质量总分及各维度得分进行统计分析。结果 生命质量总分平均值在介入术后出现明显提高 ,术前、术后 1个月及 3个月的分值分别为 :115 .4± 45 .1、12 8.1± 2 8.3、12 9.8± 46 .4(P <0 .0 1) ;维度分析示术后 1个月时 ,生理、心理、症状 3个维度得分明显上升 ,社会维度得分则下降 ,有显著差异 (P <0 .0 1) ;术后 3个月时 ,心理维度与术前无差异 ,而生理、症状、社会维度则与术前仍有显著差异(P <0 .0 5 )。结论 总体上介入治疗能够提高中、晚期肝癌患者的生命质量。提高程度与患者肝癌分期、肝功分级和介入治疗方法等密切相关。生命质量评价有望成为肝癌介入治疗效果评价的一种新途径
Objective To understand the quality of life and postoperative changes of patients with primary liver cancer before interventional therapy. MATERIALS AND METHODS The quality of life of 175 patients with primary liver cancer undergoing interventional treatment in 3 hospitals in Guangdong Province was assessed using the Hepatoma Specific Life Quality Rating Scale compiled by Wan Chonghua et al. The investigation time was before surgery, 1 month and 3 months after surgery, and the total quality of life scores and the scores of each dimension at 3 time points were statistically analyzed. Results The average score of total quality of life increased significantly after interventional operation. The scores of preoperative and postoperative 1 month and 3 months were 115.4 ± 45.1, 8.18 ± 2 8.3,12 9.8 ± 46. 4 (P <0. 01). The dimension analysis showed that at 1 month after operation, the score of physical, psychological and symptom obviously increased while the score of social dimension decreased, with significant difference (P <0.01) ). At 3 months after operation, there was no difference in the psychological dimension between preoperative and postoperative symptoms, while the social and social dimensions were still significantly different from preoperative values (P <0.05). Conclusion Overall, interventional therapy can improve the quality of life of patients with advanced liver cancer. The degree of improvement is closely related to the staging of liver cancer, grade of liver function and interventional therapy. Quality of life evaluation is expected to become a new way to evaluate the effect of interventional treatment of liver cancer