论文部分内容阅读
铜蓝蛋白、脂结合唾液酸作为肿瘤标志物在恶性肿瘤的诊断中具有一定的意义。本文用对苯二胺法测定了正常人及肿瘤患者血清中铜蓝蛋白的氧化酶活性，用改良硫代巴比妥酸法测定了正常人及肿瘤患者血清中脂结合唾液酸的含量，对数据作统计分析及ｔ检验。结果表明：肺癌、胃癌、食管癌、肠癌、肝癌、乳腺癌患者血清中铜蓝蛋白的氧化酶活性均比正常人增高，阳性率依次为：８０．０％，５２．９％，７３．３％，６６．７％，９０．０％，４４．４％。血清中脂结合唾液酸的含量在以上六种肿瘤患者中均较正常人明显增高。均有统计学意义（Ｐ＜０．０５）。说明这两种肿瘤标志物对临床诊断可以提供有价值的线索，但应注意假阳性、假阴性的控制。
Ceruloplasmin and lipid-associated sialic acid have certain significance in the diagnosis of malignant tumors as tumor markers. The oxidase activity of ceruloplasmin in the serum of normal and cancer patients was measured by the p-phenylenediamine method. The content of lipid-associated sialic acid in normal and cancer patients was determined by modified thiobarbituric acid method. Data for statistical analysis and t test. The results showed that the oxidase activities of ceruloplasmin in serum of patients with lung cancer, gastric cancer, esophageal cancer, colon cancer, liver cancer, and breast cancer were all higher than those in normal subjects. The positive rates were: 80.0%, 52.9%, 73. 3%, 66.7%, 90.0%, 44.4%. The content of lipid-associated sialic acid in the serum was significantly higher in the above six cancer patients than in normal individuals. All had statistical significance (P<0.05). It shows that these two tumor markers can provide valuable clues for clinical diagnosis, but attention should be paid to the control of false positives and false negatives.