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目的观察2型糖尿病空腹血糖经过饮食,运动,口服降糖药长期治疗仍难以控制的患者予以睡前加用不同剂量中效胰岛素(NPH)治疗效果观察。方法将确诊为2型糖尿病患者40例随机分为两组,对照组为饮食+运动+口服降糖药物治疗,治疗组为饮食+运动+口服降糖药物+睡前中效胰岛素治疗。结果治疗组降糖效果明显,无一例发生夜间低血糖反应。结论中国2型糖尿病防治指南(2010年)明确指出,2型糖尿病患者在生活方式和口服降糖药联合治疗的基础上,如果血糖仍为达到控制目标,即可开始口服药和胰岛素联合治疗[1]。
Objective To observe the effect of fasting blood glucose on type 2 diabetes after long-term treatment of diet, exercise and oral hypoglycemic agents which is still difficult to control before bedtime plus different doses of medium-acting insulin (NPH). Methods Forty patients diagnosed with type 2 diabetes were randomly divided into two groups. The control group was treated with diet + exercise + oral hypoglycemic drugs. The treatment group was diet + exercise + oral hypoglycemic drugs + bedtime insulin therapy. Results The treatment group, hypoglycemic effect was obvious, no case of nocturnal hypoglycemia. Conclusion The Guideline for Prevention and Treatment of Type 2 Diabetes in China (2010) clearly pointed out that patients with type 2 diabetes can start the oral medication and insulin combination therapy on the basis of the combination therapy of lifestyle and oral hypoglycemic agents [ 1].