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目的:优选凉血活血软胶囊中当归、羌活和独活的超临界提取工艺。方法:采用正交试验设计,以挥发油、藁本内酯和异欧前胡素判定指标,考察萃取压力、CO2流量、萃取时间和萃取温度4个因素对提取工艺的影响。结果:各因素影响大小依次为萃取压力>CO2流量>萃取时间>萃取温度,其中萃取压力对提取有明显影响(P<0.05),其他因素影响不明显(P>0.05)。结论:优选最佳工艺条件分别为萃取压力:35MPa,CO2流量:30 L·h-1,萃取温度:50℃,萃取时间:1.5 h。
OBJECTIVE: To optimize the supercritical extraction process of Angelicae Sinensis, Notopterygium incisum and Acanthopanax senticosus in Liangxue Huoxue Soft Capsule. Methods: The effects of extraction pressure, CO2 flow rate, extraction time and extraction temperature on the extraction process were investigated by orthogonal design. The volatile oil, ligustilide and isoimperatorin were determined. Results: The order of the influencing factors was extraction pressure> flow rate of CO2> extraction time> extraction temperature. Extraction pressure had obvious influence on extraction (P <0.05), and other factors had no significant effect (P> 0.05). Conclusion: The optimal process conditions are extraction pressure 35MPa, CO2 flow 30 L · h-1, extraction temperature 50 ℃, extraction time 1.5 h.