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硫化氢(H2S)作为一种有毒气体,人类认识和研究其作用已有300多年的历史。直到20世纪90年代中期,人们才发现H2S是存在生物体内的一种新型的内源性气体信号分子。H2S首先被报道是一种存在于脑内的神经递质,生理浓度的H2S对神经系统海马的长时程增强功能具有重要的调节作用。近年来,越来越多的研究证实,H2S在自发性高血压、慢性阻塞性肺气肿、脓毒血症或出血性休克、阿尔茨海黙病、胃黏膜损伤及肝硬化等多种疾病过程中发挥着重要的病理生理效应,而其作用特点有别于另外两种气体信号分子NO及CO。内源性H2S是一种新的气体信号分子,对其进一步研究是当前生物医学领域的崭新课题,具有重要的理论和临床意义。
Hydrogen sulfide (H2S) as a toxic gas, human understanding and research its role has been 300 years of history. It was not until the mid-1990s that H2S was found to be a novel endogenous gas signaling molecule in living organisms. H2S was first reported to be a neurotransmitter present in the brain. Physiological concentrations of H2S play an important regulatory role in the long-term potentiation of the hippocampus of the nervous system. In recent years, more and more studies have confirmed that H2S in spontaneous hypertension, chronic obstructive emphysema, sepsis or hemorrhagic shock, Alzheimer’s disease, gastric mucosal injury and cirrhosis and other diseases The process plays an important pathophysiological effects, and its role is different from the other two gas signaling molecules NO and CO. Endogenous H2S is a new gas signaling molecule, and its further research is a new topic in the field of biomedicine. It has important theoretical and clinical significance.