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目的:考察不同时机肠内营养(EN)对儿童重症急性胰腺炎(PSAP)患儿预后的影响。方法:选择汉中市中心医院收治的PSAP患儿109例,随机分为对照组52例和观察组57例。结果:治疗前,两组血清白蛋白(ALB)、前白蛋白(PA)、血红蛋白(Hb)、白细胞(WBC)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白介素-2(IL-2)和内毒素水平差异无统计学意义(P>0.05),治疗后观察组WBC、CRP、TNF-α、IL-2和内毒素水平均较对照组降低(P<0.05),ALB、PA和Hb水平无明显变化(P>0.05),观察组多器官功能障碍和腹腔感染例数明显减少(P<0.05)。结论:PASA病早期,48 h内给予EN,可降低患者外周血WBC、CRP、TNF-α、IL-2和内毒素水平,还可降低多器官功能障碍和腹腔感染的风险,但仍需大样本的数据支持。
Objective: To investigate the effect of different enteral nutrition (EN) on the prognosis of children with severe acute pancreatitis (PSAP). Methods: A total of 109 children with PSAP who were admitted to Hanzhong Central Hospital were randomly divided into control group (n = 52) and observation group (n = 57). Results: Before treatment, the serum levels of ALB, PA, Hb, WBC, CRP, TNF-α and IL- (P <0.05). After treatment, the levels of WBC, CRP, TNF-α, IL-2 and endotoxin in the observation group were lower than those in the control group (P <0.05) , ALB, PA and Hb levels did not change significantly (P> 0.05). The number of multiple organ dysfunction and abdominal infection in observation group decreased significantly (P <0.05). CONCLUSIONS: EN is administered within 48 h in early stage of PASA and can reduce the levels of WBC, CRP, TNF-α, IL-2 and endotoxin in peripheral blood of patients with PASA. It also reduces the risk of multiple organ dysfunction and abdominal infection, Sample data support.