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银杏叶粗提取物中烷基酚类化合物,如银杏酸、银杏酚、白果酚等毫无治疗价值,而且可致接触性过敏和中毒,抑制多种重要的酶系统,其潜在的致癌、致诱变作用也有报道。德国 Commission E 规定银杏叶提取物中银杏酸的含量不得超过5×10~(-6)。作者用鸡蛋试验法(HET)评价了生产 EGB761时得到的水不溶性残渣的不同部位对鸡胚胎的毒性。将在生产 EGB761的过程中,从60%丙酮提取物中分离的脂层进一步处理分别得SL-102(含银杏酸16.0%,双黄酮6.7%)、
The alkylphenol compounds in the crude extracts of Ginkgo biloba, such as ginkgolic acids, ginkgo phenols, and phenol, have no therapeutic value, and can cause contact allergies and poisoning, inhibiting many important enzyme systems, and their potential carcinogenic effects. Mutagenesis has also been reported. The German Commission E stipulates that the content of ginkgo acid in Ginkgo biloba extract must not exceed 5×10-6. The authors evaluated the toxicity of different parts of water-insoluble residues obtained in the production of EGB761 on chicken embryos using the egg test method (HET). During the production of EGB761, the lipid layer separated from the 60% acetone extract was further treated to obtain SL-102 (containing 16.0% of ginkgolic acid, 6.7% of biflavonoids),