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观察了3年半内急性前壁心肌梗塞57例病人有无心肌缺血预适应对心肌梗塞的影响。心肌梗塞前有预缺血者35例(A组),无预缺血者22例(B组)。结果,B组血小板计数较A组明显下降,而白细胞计数、肌红蛋白、心肌酶峰值、梗塞后严重并发症(心律失常、心功能不全,室壁瘤形成)及死亡率、血清血栓素A2均明显高于A组。提示:心肌缺血预适应是一种心肌内源性调控保护机制。还就缺血预适应产生心肌保护作用的机制进行了初步讨论。
The effect of myocardial ischemic preconditioning on myocardial infarction in 57 patients with acute anterior myocardial infarction in 3 years and a half was observed. There were 35 patients with pre-ischemic pre-infarction (group A) and 22 patients without pre-ischemic (group B). As a result, the platelet count of group B was significantly lower than that of group A, while the white blood cell count, myoglobin, peak of myocardial enzymes, serious complications after infarction (arrhythmia, cardiac dysfunction, aneurysm formation) and mortality, serum TXB2 Were significantly higher than the A group. Tip: Myocardial ischemic preconditioning is a cardiac endogenous regulatory protection mechanism. The mechanism of myocardial protection induced by ischemic preconditioning was also discussed preliminarily.