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目的 探讨老年学习记忆损害与海马和新皮质 GABA能神经元亚型——小白蛋白 (PV)神经元的关系。方法 通过Morris水迷宫行为检测将相同年龄老年大鼠分为老年学习记忆正常和损害两组 ,采用免疫组化方法定量计数各脑区 PV神经元数密度。结果 老年记忆损害鼠 CA3区和齿状回 PV神经元数密度较老年正常鼠明显减少 ;PV神经元数密度与大鼠在水迷宫中的行为密切相关。结论 CA3区和齿状回 PV神经元丢失可能是老年记忆损害的原因之一 ,提示 GABA能系统可能参与老年学习记忆损害。
Objective To explore the relationship between learning and memory impairments and GABAergic neurons subtypes - albumin (PV) neurons in the hippocampus and neocortex. Methods Morris water maze test was used to divide the aged rats of the same age into normal learning and memory impairment in the elderly. The number density of PV neurons in each brain region was quantified by immunohistochemistry. Results The number density of neurons in CA3 area and dentate gyrus of senile memory rats was significantly lower than that in normal aged rats. The density of PV neurons was closely related to the behavior of rats in water maze. Conclusions The loss of PV neurons in CA3 area and dentate gyrus may be one of the causes of memory impairment in old age, suggesting that GABAergic system may be involved in the learning and memory impairment in senility.