作者用灌胃和腹腔注射的给药方法,观察氮氧喹哌对大鼠实验性矽肺的治疗效果,发现两者均可降低肺重量和胶原蛋白、氨基多糖、肺组织磷脂、血磷脂的含量;矽结节纤维化轻微。肺Ⅱ型细胞增殖,均具有延缓矽肺发展的治疗效果。两者疗效无显著性差异,与磷酸喹哌纽的效果基本一致。 The authors used gavage and intraperitoneal injection method to observe the effect of nifedipine on the experimental silicosis in rats and found that both can reduce lung weight and collagen, aminopolysaccharides, lung tissue phospholipids, phospholipids ; Silicon nodules fibrosis mild. Lung type Ⅱ cell proliferation, have delayed the development of the therapeutic effect of silicosis. No significant difference between the two effects, and the effect of quinpirin phosphate is basically the same.