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研究脑缺血再灌流时线粒体磷脂含量与膜流动性改变，结果发现缺血２０ｍｉｎ再灌流１ｈ组线粒体卵磷脂（ＰＣ）、脑磷脂（ＰＥ）、心磷脂（ＣＬ）含量与膜流动性均显著降低，磷脂酶Ｃ（ＰＬＣ）抑制剂苯甲基碘酰氟化物（ＰＭＳＦ）治疗组线粒体ＰＣ、ＰＥ、ＣＬ含量与膜流动性均明显增高，并能显著地减轻海马ＣＡ１区迟发性神经元坏死，提示线粒体磷脂含量与膜的流动性密切相关，肌醇磷脂信使系统参与了缺血性脑损伤。
The changes of mitochondrial phospholipid content and membrane fluidity during cerebral ischemia-reperfusion were studied. The results showed that the mitochondrial lecithin (PC), cephalin (PE), cardiolipin (CL) (PMSF), the contents of PC, PE and CL in mitochondria and membrane fluidity of mitochondria were significantly increased, and the number of delayed neurons in CA1 area of hippocampus Necrosis, suggesting that mitochondrial phospholipid content and membrane fluidity is closely related to inositol phospholipid messenger system involved in ischemic brain injury.