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目的:观察卡培他滨同步三维适形放疗(3D-CRT)治疗老年食管癌根治术后局部复发的疗效及安全性。方法:采用回顾性分析方法,按照是否同步化疗将62例患者分为治疗组(卡培他滨同步3D-CRT)与对照组(3D-CRT),各31例。治疗组给予卡培他滨1000mg/m2,早晚2次,餐后30min口服,d1～14,21d为1个周期。评价完成2个周期的疗效、不良反应和远期疗效。结果:治疗组与对照组的有效率分别为83.87%、54.84%(P<0.05),1～2度胃肠道反应发生率分别为48.39%、25.81%(P<0.05),1～2度骨髓抑制发生率分别为35.48%、22.58%(P<0.05),1年局部控制率分别为70.97%、45.16%(P<0.05)。结论:卡培他滨同步3D-CRT治疗老年食管癌根治术后局部复发疗效确切,不良反应增加但均可耐受。
Objective: To observe the efficacy and safety of capecitabine simultaneous three-dimensional conformal radiotherapy (3D-CRT) in the treatment of local recurrence after esophagectomy in elderly patients. Methods: A retrospective analysis was performed in 62 patients (31 for each group), which were divided into treatment group (3D-CRT) and control group (3D-CRT). The treatment group was given capecitabine 1000mg / m2, morning and evening 2 times, 30min after meal oral, d1 ~ 14,21d for a cycle. Evaluation completed the 2 cycles of efficacy, adverse reactions and long-term efficacy. Results: The effective rates of the treatment group and the control group were 83.87% and 54.84%, respectively (P <0.05). The incidences of gastrointestinal reactions of 1-2 degrees were 48.39%, 25.81% (P <0.05) The incidences of myelosuppression were 35.48% and 22.58%, respectively (P <0.05). The 1-year local control rates were 70.97% and 45.16%, respectively (P <0.05). Conclusion: Capecitabine simultaneous 3D-CRT treatment of esophageal cancer in elderly patients with local recurrence of the exact effect of the adverse reactions increased but both were tolerable.